Endocrine Abstracts

Introduction: There is circumstantial evidence supporting a role of growth hormone and insulin-like growth factor 1 in the development and progression of tumors. Endosalpingiosis is characterized by the presence of non-neoplastic fallopion tube-like epithelium in ectopic anatomical locations.Case report: A 45-year-old woman presented with a constant moderate to intense perianal pain limiting basic daily life activities. She also complained about pain at ...

Sheehan’s syndrome represents a rare cause of pituitary insufficiency, produced by an ischemic pituitary necrosis due to a severe haemorrhage at deliverance. Epidemiologic data indicate that, nowadays, this disease is quite rare in developed country.Aim: To determine and evaluate the clinical and hormonal characteristics of cases with Sheehan’s syndrome diagnosed and follow-up in our Clinic, during the last ten years.Subj...

Nonadherence to levothyroxine therapy is one cause of persistent hypothyroidism. To distinguish nonadherence from malabsorption, a levothyroxine absorption test (LAT) is sometimes required. The authors report a case of a 60-year-old female patient suffering from hypothyroidism resistant to oral levothyroxine (LT4) substitution after radioiodine therapy for Graves’ disease. Despite the continuous increases of LT4, over 10 years, to a maximum of 1 mg/d...

IGFBP-2 represents a multifunctional protein with effects on growth, reproductive development, aging, and metabolism. For the expression of these diverse effects in vivo, IGFBP-2 has a number of binding sites for IGFs, integrins, and proteoglycans. In order to assess the relative contributions of these binding sites to the multiple effects of IGFBP-2, we have developed transgenic mouse models overexpressing intact or mutant IGFBP-2. Here we discuss functions of the RG...

Heat shock protein 90 (HSP90) plays a pivotal role in maturation and stabilization of proteins in conditions of stress. Many HSP90 client proteins are involved in oncogenic signaling and cancer progression, therefore HSP90 inhibitors have a potential as pharmaceutical agents. We reported a strong HSP90 overexpression in corticotroph adenomas and the treatment with C-terminal HSP90 inhibitors has potent anti-tumorigenic and anti-secretory effects in these tumors in vitro</e...

Introduction: Subacute thyroiditis (ST) is a self limited condition; relapse is rarely seen. Anterior cervical complains and inflammatory syndrome is highly suggestive.Aim: We report a series of female cases associating arelapse of ST which was confirmed after the admission for atypical distant symptoms as diffuse headache or ear pain.Material and Methods: The endocrine profile is presented.Results: A 48-year...

A number of evidence indicate that mood (affective) disorders are influenced by various bioactive steroids such as corticoids, sex hormones and neuroactive steroids. However, to date, there are limited data concerning the discrimination between patients suffering from the disorders and controls, or regarding the classification of individual subtypes of mood disorders on the basis of steroid profiling. Therefore 47 steroids including their conjugates and further related substan...

Introduction: Cushing’s disease (CD) is a rare disorder caused by an ACTH-secreting pituitary adenoma. Transsphenoidal surgery (TSS) is the recommended first-line treatment. However, an equivocal or even normal preoperative MRI can preclude the surgical management and the outcome of these patients.Objectives: Evaluate the relationship between preoperative MRI and TSS efficacy in patients with CD.Methods: Retrospective cohort s...

Objective: Microalbuminuria is usually the first microvascular complication of type 1 diabetes mellitus (T1DM). We aimed to identify its frequency, time of occurrence and related risk factors.Methods: Clinical reports of 201 children followed in our institution were retrospectively analysed (diabetes duration 3.8±3.6 years, age at diagnosis 8.1±3.7 years, HbA1c value 9.0±1.7%). Statistical analysis was performed with SPSS version.21 for Wi...

Introduction: Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) are forms of intensified insulin therapy and the most used regimens for type 1 diabetes (T1D). Owing to its continuous basal output, hypoglycaemic events tend to be rarer with CSII. Our goal was to evaluate the differences in nocturnal hypoglycemia between these two treatment strategies.Methods: Retrospective analysis of 61 patients who had performed continu...